Ganesh Cherala, Ph.D .

Department: Department of Pharmacy Practice
Location: OHSU
College of Pharmacy
Oregon Health & Science University
3303 SW Bond Ave., CH12C
Portland, OR 97239
Phone: 503-418-0447
cheralag@ohsu.edu
Table of Contents:
Education
Postdoctoral Training, Clinical Pharmacokinetics, Philadelphia College of Pharmacy, Philadelphia,
PA, 2006-2007
Ph.D.(Pharmaceutical Sciences), University of the Sciences in Philadelphia, Philadelphia, PA, 2001-2006
Bachelor of Pharmacy, Osmania University, Hyderabad, India, 1995-1999
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Position
Assistant Professor, Pharmacokinetics
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Research Area
PharmacokineticsReturn to Table of Contents
Research
Dr. Cherala’s research interests are broadly divided into the following.
- Pharmacokinetics:
Understand sources of variability in drug pharmacokinetics, with a special
emphasis on adverse early life exposure. Prenatal and/or postnatal
exposure to adverse environment has been linked to smaller birth weight
and subsequently higher incidence of metabolic syndrome diseases –
hypertension, hyperlipidemia and diabetes during adult life. Mechanistic
probing of this link suggests alterations in levels and release profiles
of growth hormone, thyroid hormones, leptin, insulin, and cytokines. These
endogenous molecules are also known modulators of various enzymes and
transporters including those involved in pharmacokinetic processes –
Absorption, Metabolism, and Excretion. His hypothesis is that early life
exposure to adverse environment will leave a permanent mark on the status
of enzymes and transporters relevant to drug pharmacokinetics. He uses biochemical (enzyme kinetics) and molecular biology (western blotting,
RT-PCR) tools in testing this hypothesis.
Modeling
Pharmacokinetic data is another aspect of his pharmacokinetic research
interests. - Bioanalysis: Another area of interest is bioanalytical
method development. Spectrophotometric and chromatographic (HPLC, LC/MS,
LC/MS/MS, GC/MS) techniques are employed in analyzing drug concentrations in
various biological matrices (Plasma, Serum and Whole Blood).
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Selected Publications
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