College of Pharmacy

Department: Department of Pharmacy Practice
Location: OHSU

College of Pharmacy
Oregon Health & Science University
3303 SW Bond Ave., CH12C
Portland, OR 97239
Phone: 503-418-0447
cheralag@ohsu.edu

Table of Contents:

• Education
• Position
• Research Area
• Research
• Selected Publications

Education

Postdoctoral Training, Clinical Pharmacokinetics, Philadelphia College of Pharmacy, Philadelphia,
PA, 2006-2007
Ph.D.(Pharmaceutical Sciences), University of the Sciences in Philadelphia, Philadelphia, PA, 2001-2006
Bachelor of Pharmacy, Osmania University, Hyderabad, India, 1995-1999

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Position

Assistant Professor, Pharmacokinetics

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Research Area

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Research

Dr. Cherala’s research interests are broadly divided into the following.

1. Pharmacokinetics:
   Understand sources of variability in drug pharmacokinetics, with a special
   emphasis on adverse early life exposure. Prenatal and/or postnatal
   exposure to adverse environment has been linked to smaller birth weight
   and subsequently higher incidence of metabolic syndrome diseases –
   hypertension, hyperlipidemia and diabetes during adult life. Mechanistic
   probing of this link suggests alterations in levels and release profiles
   of growth hormone, thyroid hormones, leptin, insulin, and cytokines. These
   endogenous molecules are also known modulators of various enzymes and
   transporters including those involved in pharmacokinetic processes –
   Absorption, Metabolism, and Excretion. His hypothesis is that early life
   exposure to adverse environment will leave a permanent mark on the status
   of enzymes and transporters relevant to drug pharmacokinetics. He uses biochemical (enzyme kinetics) and molecular biology (western blotting,
   RT-PCR) tools in testing this hypothesis.
   Modeling
   Pharmacokinetic data is another aspect of his pharmacokinetic research
   interests.
2. Bioanalysis: Another area of interest is bioanalytical
   method development. Spectrophotometric and chromatographic (HPLC, LC/MS,
   LC/MS/MS, GC/MS) techniques are employed in analyzing drug concentrations in
   various biological matrices (Plasma, Serum and Whole Blood).

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Selected Publications

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