Senior Research/Assistant Professor
Department of Pharmaceutical Sciences
College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331
Phone: 541-737-9416
indrag@onid.orst.edu
Research Associate, IGBMC, Strasbourg-CĂ©dex FRANCE, 2004-2005
PDF, IGBMC, Strasbourg-CĂ©dex FRANCE, 2001-2003
Ph.D., University of Louis Pasteur, FRANCE, 2001
Master of Science, Andhra University, India
Skin, the largest organ in the body, protects us from the external arid, toxic environment through establishment of the epidermal permeability barrier (EPB). The degree of redundancy and complexity to establish the EPB is remarkable, and lot remains to be learned regarding the involved molecular pathways and the underlying compensatory mechanism. To survive the transition from an aqueous in utero to an external environment, mice and humans must construct an epidermal permeability barrier in utero. Our group focused to study the role of transcriptional regulators like, Chicken ovalbumin upstream promoter transcription factor (COUP-TF)–interacting protein2 (CTIP2/ Bcl11b), in epidermal homeostasis and barrier formation. Preliminary experiments of characterization of CTIP2 expression during mouse embryogenesis using CTIP2 specific antibody revealed high expression of CTIP2 in skin. Our central hypothesis is that CTIP2 in a cell autonomous manner mediate formation of EPB in the developing skin, and regulate expression of genes that are involved in barrier establishment. Successful completion of the project is expected to provide better understanding of the complex compensatory mechanism underlying EPB formation, and help develop novel strategies to treat patients with related disorders like AD and psoriasis
Ganguli, G., Indra, A. and Gupta P. (1998): Suitability of the follicular oocytes obtained from slaughtered buffalo ovaries and assessment of their nuclear maturation. Buffalo. J. 2: 217-227.
Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.Ganguli, G., Indra, A. and Gupta P. (1998): Suitability of the follicular oocytes obtained from slaughtered buffalo ovaries and assessment of their nuclear maturation. Buffalo. J. 2: 217-227.
Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.
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Oregon State University
203 Pharmacy Building
Corvallis, OR 97331
Phone: 541-737-9416
indrag@onid.orst.edu
College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331
Phone: 541-737-9416
indrag@onid.orst.edu
Research Associate, IGBMC, Strasbourg-CĂ©dex FRANCE, 2004-2005
PDF, IGBMC, Strasbourg-CĂ©dex FRANCE, 2001-2003
Ph.D., University of Louis Pasteur, FRANCE, 2001
Master of Science, Andhra University, India
Skin, the largest organ in the body, protects us from the external arid, toxic environment through establishment of the epidermal permeability barrier (EPB). The degree of redundancy and complexity to establish the EPB is remarkable, and lot remains to be learned regarding the involved molecular pathways and the underlying compensatory mechanism. To survive the transition from an aqueous in utero to an external environment, mice and humans must construct an epidermal permeability barrier in utero. Our group focused to study the role of transcriptional regulators like, Chicken ovalbumin upstream promoter transcription factor (COUP-TF)–interacting protein2 (CTIP2/ Bcl11b), in epidermal homeostasis and barrier formation. Preliminary experiments of characterization of CTIP2 expression during mouse embryogenesis using CTIP2 specific antibody revealed high expression of CTIP2 in skin. Our central hypothesis is that CTIP2 in a cell autonomous manner mediate formation of EPB in the developing skin, and regulate expression of genes that are involved in barrier establishment. Successful completion of the project is expected to provide better understanding of the complex compensatory mechanism underlying EPB formation, and help develop novel strategies to treat patients with related disorders like AD and psoriasis
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Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.Ganguli, G., Indra, A. and Gupta P. (1998): Suitability of the follicular oocytes obtained from slaughtered buffalo ovaries and assessment of their nuclear maturation. Buffalo. J. 2: 217-227.
Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331
Phone: 541-737-9416
indrag@onid.orst.edu
Ganguli, G., Indra, A. and Gupta P. (1998): Suitability of the follicular oocytes obtained from slaughtered buffalo ovaries and assessment of their nuclear maturation. Buffalo. J. 2: 217-227.
Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331
Phone: 541-737-9416
indrag@onid.orst.edu
Ganguli, G., Indra, A. and Gupta P. (1998): Suitability of the follicular oocytes obtained from slaughtered buffalo ovaries and assessment of their nuclear maturation. Buffalo. J. 2: 217-227.
Ganguli, G., Alkhalaf, M., Messadeq, N., LeMeur, M. and Wasylyk, B. (1999). MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene. Feb 18: 1419-1934.
Ganguli, G., Abecassis, J. and Wasylyk B. (2000). MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J. 19(19): 5135-5147.
Ganguli, G., Back, J., Sengupta, S. and Wasylyk B. (2002). The p53 tumour suppressor inhibits glucocorticoid induced proliferation of erythroid progenitors. EMBO Reports.June; 3(6):569 –574.
Cromer, A., Carles, A., Million, R., Ganguli, G., Lemaire, F.,Young, J., Dembélé, D., Thibault, C., Diemunsch, F., Abecassis, J. and Wasylyk B.(2003). Molecular classification of Head and Neck Squamous Cell Carcinoma, Oncogene, Dec;1-15 (First 3 are equal first authors and GG is second author).
Ganguli G. and Wasylyk B.(2003). p53 independent functions of MDM2. Molecular Cancer Research,Dec;1(14):1027-35.
Nakade, K., Ganguli, G., Hong, Z., and Wasylyk B. (2004). Functional interaction between tumor suppressor p53 and Net, Mol Cell Biol., Feb;24(3):1132-42. (HZ and GG are equal second authors).
Carles A., Millon R., Cromer A., Ganguli G., Lemaire F., Young J., Wasylyk C., Muller D., Schultz I., Rabouel Y., Dembele D., Zhao C., Marchal P., Ducray C, Bracco L., Abecassis J., Poch O., Wasylyk B. (2005). Head and Neck Squamous Cell Carcinoma (HNSCC) transcriptome analysis by comprehensive validated differential display. Oncogene., Oct 31.
Seghatoleslam, A., Zambrano, A., Millon, R.,Ganguli, G., Abecassis J., & Wasylyk, B. (2006). Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. BBRC, Jan 6;339(1):422-9.
Rodius, S., Indra (nee Ganguli), G., Thibault, C., Pfister, V., Georges-Labouesse, E. (2007). Loss of a6 integrins in keratinocytes leads to an increase in TGFb and AP-1 signaling and in expression of differentiation genes. J Cell Physiol. 2007 Aug;212(2):439-49.
Golonzhka, O., Leid, M., Indra, G#., Indra, A.K. # (2007). Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. Aug;7(7):754-60.