Associate Professor, Pharmaceutics
Department of Pharmaceutical Sciences
College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331-3507
Phone: 541-737-5788
JMark.Christensen@oregonstate.edu
University of Utah, Ph.D., 1980; B.S., 1975.
J. Mark Christensen's research takes three basic thrusts within the areas of biopharmaceutics, pharmacokinetics and drug dosage formulation. In response to the growing importance of drug therapy in animals, one research area, done in collaboration with faculty from the College of Veterinary Medicine, looks at drug disposition in animals. In another area, similar research techniques are applied to determining drug dosing and disposition in humans — how drugs are absorbed, eliminated and metabolized. The third research interest involves bacterial vaccines for use in fish. Having already improved the three existing vaccines for salmonids in terms of cost and effectiveness, planning has turned to developing new and even more effective vaccines for other bacterial fish diseases.
Ehab R. Bendas, J. Mark Christensen, James W. Ayres. “Development and In-vitro Evaluation of Mesalamine Delayed-Release Pellets and Tableted Reservoir-Type Pellets”. Accepted for Publication August 27,2009. Drug Development and Industrial Pharmacy.Â
Sahar A. Fahmy, J. Mark Christensen, James W. Ayres, “Development of a Novel Spay Coated Soft Elastic Gelatin Capsule Sustained Release Formulations of Nifedipine.” Drug Development and Industrial Pharmacy. August (2009), Volume 35(8):1009-1021.Â
Monica C. Chuong, J. Mark Christensen, and James W. Ayres, “Sustained Delivery of Intact drug to the Colon: Mesalamine Formulation and temporal Gastrointestinal Transit Analysis,” Pharmaceutical Technology and Development, February (2009), Volume 14 (no. 1):116-125.
Monica C. Chuong, J. Mark Christensen, James W. Ayres, “New Dissolution Method for Mesalamine Tablets and Capsules,” Dissolution Technologies. (2008, August), Volume 15, issue 3:7-14.Â
David Bearden, George Allen, J. Mark Christensen, “Comparative in Vitro Activities of Topical Wound Care Products Against Community-Associated Methicillin-Resistant Staphylococcus Aureus”, Journal of Antimicrobial Chemotherapy, (2008), Volume 62:769-772.Â
Ursula Bechert, J. Mark Christensen, Chien Nguyen, Roopesh Neelkant, and Ehab Bendas, “Pharmacokinetics of Orally Administered Phenylbutazone in African and Asian Elephants (Loxodonta Africana and Elephas Maximus)”, Journal of Zoo and Wildlife Medicine, (2008) 39(2):188-200.Â
Chien N. Nguyen, J. Mark Christensen, James W. Ayres, Formulation of Sustained Release Verapamil HCl and Diltiazem HCl Solid Matrix Capsules, Pharmaceutical Development and Technology, (2008) 13(2):115-125. Â Â
Grant Beardsley, and John Mark Christensen, Elimination of 11-nor-9-Carboxy-delta-9-Tetrahydrocannabinol when Normalized to Urinary Creatinine, Research Communications in Molecular Pathology and Pharmacology, (Accepted for Publication on September 17, 2007).Â
Prapoch Watanalumerd, J. Mark Christensen, and James W. Ayres, “Pharmacokinetic Modeling and Simulation of Gastrointestinal Transit Effects of Plasma Concentration of Drug from Mixed Immediate-Release and Enteric-Coated Pellets” Pharmaceutical Development and Technology (2007) 12(2): 193-202.
Ursula Bechert, J. Mark Christensen, “Pharmacokinetics of Orally Administered Ibuprofen in African and Asian Elephants (Loxodonta Africana and Elephas Maximus). Journal of Zoo and Wildlife Medicine (2007) 38 (2):258-268. Â
Ursula Bechert, Patrick Redig, Jeff Wyatt, Robert Poppenga and Mark Christensen. “Pharmacokinetics and Clinical Efficacy of Terbinafine Against Aspergillosis in Avian Species”. Proceedings of American Association of Zoo Veterinarians. (2004) Pages 241-244.
Ursula Bechert, J. Mark Christensen, and M. Finegan. “Pharmacokinetics of Orally Administered Ibuprofen in Elephants”. Proceedings of American Association of Zoo Veterinarians. (2003) pages 84-85.
Christensen JM, Limsakum T, Smith BB, Holinghead N, Huber M. Pharmacokinetics of Antipeptic Agents in Llamas. Journal of Veterinary Pharmacology and Therapeutics. 2001;24:23-33.Â
Smith BB, Timm KI, Reed PJ, Christensen JM. Use of Cloprostenol as an Abortifacient in the Llama (lama gama). Theriogenology. 2000;54:497-505.
Kalnsand J, Christensen JM. Thrombomodulin like activity following intravenous injection of non-ionic surfactants in rats. Research Communications in Pharmacology and Toxicology. 2000;5:3-10.
Piganelli J, Wiens G, Zhang AJ, Christensen JM, Kaattari SL. Evolution of Whole Cell p-57 Vaccine Against Renebacterium Salmoninarum. Diseases of Aquatic Organisms. 1999;36:37-44.
Christensen JM, Smith BB, Murdande SB, Holingshead N. The Disposition of Five Therapeutically Important Antimicrobial Agents in Llamas. Journal of Veterinary Pharmacology and Therapeutics. 1996;19:431-438.
Zhang AJ, Christensen JM. Effect of Superdisintegrant on Antigen Release from Enteric-Coated Antigen Microspheres. Drug Development and Industrial Pharmacy. 1996;22(8):833-839.
Piganeli J, Zhang AJ, Christensen JM, Kaattari SL. Enteric Coated Microspheres as an Oral Method for Antigen Delivery to Salmonide. Fish and Shellfish Immunology. 1994;4:179-188.
Wong G, Kaattari SL, Christensen JM. Effectiveness of an Oral Enteric Coated Vibrio Vaccine for Use in Salmonid Fish. Immunological Investigations. 1992;21(4):353-364.
Christensen JM, Stalker D. Ibuprofen Piconol Hydrolysis in Plasma, Whole Blood and Serum Using Different Anticoagulants. Journal of Pharmaceutical Science. 1991;80:29-31.
Duffee N, Christensen JM. The Pharmacokinetics of Cefadroxil in the Foal. Journal of Veterinary Pharmacological Therapy. 1989;12(2):322-326.
United Kingdom: Number 2308300, Renebacterium Salmoninarum Vaccine and Method of It's Preparation. Granted: September 2, 1998. Inventors: J.M. Christensen, S. Kaattari, J. Piganelli, G. Wiens, A.J. Zhang.
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United States: Number 5871751, Renebacterium Salmoninarum Vaccine and Method of It's Preparation. Granted February 16, 1999. Inventors: J.M. Christensen, S. Kaattari, J. Piganelli, G. Wiens, A.J. Zhang.
