Assistant Professor, Pharmacology
Department of Pharmaceutical Sciences
College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331-3507
Phone: 541-737-5783
Jane.Ishmael@oregonstate.edu
National Institute on Drug Abuse Postdoctoral Fellow, 1996-1999
Oregon State University, Postdoctoral Training, 1995-1999
Oregon State University, Ph.D., 1995
University of Bradford, England, Bachelor of Science, 1988
Glutamate is the major excitatory neurotransmitter in the central nervous system and is essential for synaptic transmission and synaptic plasticity associated with development, learning and the formation of memories. Excessive activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor and the subsequent disruption of intracellular calcium homeostasis, is also known to play a central role in the pathophysiology of ischemic stroke. Excitatory neuronal synapses in brain are enriched with proteins that anchor, cluster and target glutamate receptors for optimal signal transduction at the postsynaptic membrane within a specialized structure known as the postsynaptic density (PSD). Jane Ishmael is particularly interested in the interaction of NMDA receptors with various cytoskeletal proteins that are found in the PSD of mature synapses. She uses a variety of biochemical and molecular biological techniques to study these protein-protein interactions. Her goal is to understand the functional organization of protein complexes at excitatory synapses and the role of intracellular NMDA receptor-interacting proteins in glutamate receptor signaling.
Amparan D, Avram D, Thomas CG, Lindahl MG, Yang J, Bajaj G, Ishmael JE. Direct interaction of Myosin Regulatory Light Chain with the NMDA receptor. Journal of Neurochemistry. 2005;92:349-361.
Lepage KT, Ishmael JE, Low CM, Traynelis SF, Murray TF. Differential binding properties of [ 3H]dextrorphan and [ 3H] MK-801 in heterologously expressed NMDA receptors. Neuropharmacology. 2005;49:1-16.
Leid M, Ishmael JE, Avram D, Shepherd D, Fraulob V, Dolle P. CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis. Gene Expression Patterns. 2004;4:733-739.
Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Lee S-H, Ishmael JE, Leid M. Isolation of a novel family of C2H2 zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. Journal of Biological Chemistry. 2000;275:10315-1032.
Nevrivy DJ, Peterson VJ, Avram D, Ishmael JE, Hansen SG, Dowell P, Hruby DE, Dawson MI, Leid M. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. Journal of Biological Chemistry. 1999;275:16827-16836.
Dowell P, Ishmael JE, Avram D, Nevrivy DJ, Leid M. Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor a interacting protein. Journal of Biological Chemistry. 1999;274:15901-15907.
Avram D, Ishmael JE, Nevrivy DJ, Lee S-H, Dowell P, Leid M. Heterodimeric interactions between COUP-TF family members ARP1 and Ear2. Journal of Biological Chemistry. 1999;274:14331-14336.
