Professor Emeritus, Medicinal Chemistry
Professor Emeritus, College of Pharmacy
Department of Pharmaceutical Sciences
College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331-3507
Phone: 541-737-5779
John.Block@oregonstate.edu
Stanford University, N.I.H. Special Postdoctoral Fellow and Visiting Scholar, 1972-73
University of Wisconsin, Ph.D., 1966
Washington State University, M.S., 1963
B.Phar., B.S., 1961
John Block’s research into quantitative structure activity relationships (QSAR) seeks to describe chemical models mathematically, defining equations that will predict or explain biological responses. He has investigated the use of chemical graph theory in QSAR studies and the application of multivariate statistics to search for underlying relationships among biologically active molecules. One collaborative project looks at the current controversy over the action of general anesthesia and dispersion interaction with receptors in the nervous system.
Block JH. Physicochemical Properties in Relation to Biological Action. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed. Philadelphia: Lippincott-Raven; Chapter 2.
Block JH, Antimalarias. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed. Philadelphia: Lippincott-Raven; Chapter 11.
Cutler SJ, Block JH. Drug Metabolism. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed. Philadelphia: Lippincott-Raven; Chapter 4.
Block JH. Selective Toxicity. In: Abraham D, ed. Burger’s Medicinal Chemistry and Drug Discovery, 6th ed., Vol 5. New York: John Wiley & Sons; 2003:249-280.
Block JH. Vitamins. In: Abraham D, ed. Burger’s Medicinal Chemistry and Drug Discovery, 6th ed., Vol. 4. New York: John Wiley & Sons; 2003:359-420.
Block JH, Yu Y, King JW, Verloop A. A Quantitative Structure Activity Relationships Study of Antiinfectives Based on the Nalidixic Acid Structure. In: Magee PS, Henry DR, Block JH, eds. Probing Bioactive Mechanisms by Modeling and Statistical Inference. ACS Symposium Series #413, Washington, D.C.: ACS Books; 1989:301-350. (This chapter is a retrospective study that isolated the important structural elements and determined their effectiveness from among 100 synthesized compounds.)
Chiou CT, Block JH. Parameters affecting the partitin coefficients of organic compounds in solvent-water and lipid-water systems. In: Dunn WJ, Block JH, Pearlman RS, eds. Partition Coefficient: Determination and Estimation. New York: Pergamon Press; 1986:37-60.
