College of Pharmacy

Department: Department of Pharmaceutical Sciences
Location: OSU

College of Pharmacy
Oregon State University
203 Pharmacy Building
Corvallis, OR 97331-3507
Phone: 541-737-5786
Rosita.Proteau@oregonstate.edu 

Table of Contents:

• Education
• Position
• Research Area
• Research
• Selected Publications

Education

University of Texas at Austin, B.S., 1991; Ph.D., 1996

Return to Table of Contents

Position

Associate Professor, Pharmaceutics

Return to Table of Contents

Research Area

Return to Table of Contents

Research

Rosita Proteau's research focuses on the development of in vitro cellular models to explore and evaluate the mechanism by which xenobiotics damage or injure specific cell types of various organs or tissues. Rosita works with primary culture systems of liver, heart and skin as experimental models to study the cellular and subcellular toxicity of selected xenobiotics using sensitive indices of cytotoxicity. She also performs drug transport and metabolism studies using a variety of intestinal models. 

Return to Table of Contents

Selected Publications

Peluso, M.R., Miranda, C.L., Hobbs, D.J., Buhler, D.R., Rodriguez-Proteau, R. and Stevens, J.F. . Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: Structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). Planta Medica, Epub March 22, 2010.

Bajaj, G., Rodriguez-Proteau, R., Venkataraman, A., Fan, Y., Kioussi, C. and Ishmael, J. E. . MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain, Biochemical Biophysical Research Communications, 398, 7 - 12, 2010.

Taur , J.-S. and Rodriguez-Proteau, R. Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models.  Xenobiotica, 38: 1536 - 1550. 2008.

Fan, Y. and Rodriguez-Proteau, R. "Effects of ketoconazole on multidrug resistant-mediated transport in Caco-2 and MDCK-MDR1 drug transport models. Xenobiotica, 38: 107 - 129. 2008. 

Mata, J.E., Dyal, L.A., Slauson M.E., Loehr, C., Summerton J.E., Tyson, A.R., Rodriguez-Proteau, R., Gustafson, S.B. Tumor imaging using technicium-99m bound to pH sensitive peptides. Nanomedicine. Nanotechnology, Biology, and Medicine, Volume 3, 297 – 305, 2007.

von Borstel Smith, M., Crofoot, K., Rodriguez-Proteau, R., and T.M. Filtz. "Effects of phenytoin and carbamazepine on calcium transport in Caco-2 cells" Toxicology in Vitro. 2007; 21: 855-862.

Rodriguez-Proteau R, Mata JE, Miranda CL, Fan Y, Brown JJ, Buhler DR. Plant Polyphenols and Multi-Drug Resistance: Effects of Dietary Flavonoids on Drug Transporters in Caco-2 and MDCK-MDR1 cell transport models. Xenobiotica. 2006;36:41-58.

Mahadevan B, Mata JE, Albershardt DJ, Stevens JF, Pereira CB, Rodriguez-Proteau R, Baird WM. The effects of red raspberry extract on PAH transport across Calu-3 cell monolayer, an in vitro cell model. International Journal Cancer Prevention. 2005;2:129-141.

Rodriguez-Proteau R, Grant RL. Toxicity Evaluation and Human Risk Assessment of Surface and Ground Water Contaminated by Recycled Hazardous Waste Materials. In: Environmental Impact Assessment of Recycled Wastes on Surface and Ground Waters. Volume 2: Risk Analysis. The Handbook of Environmental Chemistry, Water Pollution Series, Vol. 5/Part F. Heidelberg-New York: Springer-Verlag; 2005:533 pp.

Blatt DH, Pryor WA, Mata JE, Blatt JM, Rodriguez-Proteau R. Reevaluation of the relative potency of synthetic and natural alpha-tocopherol: Experimental observations and clinical trials. Journal of Nutritional Biochemistry. 2004;15:380-395.

Mata JE, Yu Z, Gray JE, Williams DE, Rodriguez-Proteau R. Effects of chlorophyllin on transport of dibenso(a,l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and aflatoxin B1 across Caco-2 cell monolayers. Toxicology. 2004;196:117-125.

Rodriguez RJ, Buckholz CJ. Hepatotoxicity of ketoconazole in Sprague Dawley rats: Glutathione depletion, flavin-containing monooxygenases-mediated bioactivation, and hepatic covalent binding. Xenobiotica. 2003;33:429-441.

Grant RL, Rodriguez RJ, Hofelt CS, Haws LC. Evaluation of phthalate Kow Values and the phthalate metabolism factor for use in mutlipathway risk assessment of hazardous waste combustion facilities. Human Ecological Risk Assessment. 2002;8:1137-1154.

Rodriguez RJ, Acosta D. Cardiac Toxicology. In: Sperelakis N, Kurachi Y, Terzic A, Cohen MV, eds. Heart Physiology and Pathophysiology. San Diego: Academic Press; 2001:1211-1224.

Rodriguez RJ, Miranda CL, Stevens JF, Deinzer ML, Buhler DR. Influence of prenylated and non-prenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes. Food and Chemical Toxicology. 2001;39:437-445.

Rodriguez RJ, Miranda CL. Isoform Specificity of N-Deacetyl Ketoconazole by Human and Rabbit lavin-Containing Monooxygenases. Drug Metabolism and Disposition. 2000;28:1083-1086.

Rodriguez RJ, Proteau PJ, Marquez B, Hetherington CL, Buckholz CJ, O'Connell KL. Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole in rat hepatic microsomes. Drug Metabolism and Disposition. 1999;27:880-886.

Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yea-Huey Y, Deinzer ML, Barnes DW, Buhler DR. Antiproliferative and cytotoxic effects of prenylated flavonoids from HOPS (Humulus Lupulus) in human cancer cell lines. Food and Chemical Toxicology. 1999;37:271-285.

Davila JC, Rodriguez RJ, Melchert RB, Acosta D. Predictive value of in vitro model systems in toxicology. Annual Review of Pharmacology and Toxicology. 1998;38:63-96.

Rodriguez RJ, Acosta D. Metabolism of ketoconazole and N-deacetyl ketoconazole by rat hepatic microsomes and flavin-containing monooxygenases. Drug Metabolism and Disposition. 1997;25:772-777.

Rodriguez RJ, Acosta D. N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes. Toxicology. 1997;117:123-131.

Rodriguez RJ, Acosta D. Inhibition of mitochondrial function in isolated rat liver mitochondria by azole antifungals. Journal of Biochemical Toxicology. 1996;11:127-131.

Rodriguez RJ, Davila JC, Acosta D. Establishment of flavin-containing monooxygenases in hepatic microsomes obtained from primary cultures of rat hepatocytes. Toxicologist. 1996;30:1215.

Rodriguez RJ, Acosta D. Comparison of ketoconazole- and fluconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes. Toxicology. 1995;96:83-92.

Smith PC, Song WQ, Rodriguez RJ. Covalent binding of etodolac acyl glucuronide to albumin in vitro. Drug Metabolism and Disposition. 1992;63:221-223.

Return to Table of Contents