Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Travels and Professional Service:
Block J was elected to a three year term on the Oregon State University Retirees Association Board of Directors.
Filtz T served as Co-coordinator, Colloquium on G protein Targets, sponsored by the American Society for Pharmacology and Experimental Therapeutics, at EB’09, New Orleans, LA, April 17-18, 2009.
Invited Presentations:
Block J. Reader’s Digest Overview of Medicare. March 8, 2009. Oregon State Pharmacy Association Spring Continuing Education Program.
Cui Z. Towards rational vaccine delivery. March 26, 2009. University of Michigan, Department of Microbiology and Immunology.
Cui Z. Rational vaccine/drug delivery. April 29, 2009. University of North Carolina, Chapel Hill, Eshelman School of Pharmacy.
Filtz T. Gq/Phospholipase C-beta signaling in cardiomyocyte hypertrophy and atrial dilatation. March 11, 2009. Vollum Institute, OHSU, Portland, Oregon.
Research Posters and Oral Presentations:
Filtz T, Grubb M, E. A. Woodcock. The b splice variant of PLC-beta1 selectively mediates alpha1 receptor- and Gq-coupled hypertrophy in cardiomyocytes. (poster) April 19, 2009. American Society for Pharmacology and Experimental Therapeutics/EB’09, New Orleans, Louisiana.
Stevens J. Xanthohumol from Hops (Humulus lupulus) in the Complementary Treatment of Metabolic Syndrome-related Disorders. (platform presentation) Symposium for Portland Area Research (SPARC) on Complementary and Alternative Medicine: Emerging Directions in CAM Research. April 18, 2009. Oregon Health and Science University, Portland, Oregon. This symposium was attended by 225 participants including the Director of the National Center for Complementary and Alternative Medicine (NCCAM/NIH).
Publications:
Zhang Y, Kwon S, Vogel W, Filtz, T. PI(3,4,5)P3 potentiates phospholipase C-beta activity. J. Recept Sig. Trans. 2009, 29:52-62.
Mahmud, T. Progress in Aminocyclitol Biosynthesis. Curr. Opin. Chem. Biol. 2009, 13: 161-170.
Fotso S, Zabriskie TM, Proteau PJ, Flatt PM, Santosa DA, Sulastri, Mahmud, T. Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp. J. Nat. Prod. 2009, 72: 690-695.
Stevens JF, Reed RL, Alber S, Pritchett L, Machado S. Herbicidal activity of glucosinolate degradation products in fermented meadowfoam (Limnanthes alba) seed meal. Journal of Agricultural and Food Chemistry. 2009, 57: 1821-1826.
Chung WG, Miranda CL, Stevens JF, Maier CS. Hop Proanthocyanidins Induce Apoptosis, Protein Carbonylation, and Cytoskeleton Disorganization in Human Colorectal Adenocarcinoma Cells via Reactive Oxygen Species. Food Chem. Tox. 2009, 47(4):827-36.
Honors and Awards:
Hyter S (Indra Group) received the outstanding podium presentation award for his talk on “Cooperative effects of keratinocytic RXR and CDK4 in melanoma metastasis”. College of Pharmacy Annual Rising Lecture, (April 3, 2009, Salishan Resort).
Business plan “NeoHope” developed by MBA Masters students based on “CTIP2 expression as a novel biomarker for Head and Neck Squamous Cell carcinoma progression”, Indra G, Indra AK, Leid M, received 3rd Place overall and won “People's Choice Award” in the 2009 Austin Enterprise Challenge competition. La Sells Stewart Center, Oregon State University, Corvallis, Oregon. April 17, 2009.
Indra G’s work to develop “CTIP2 as a novel biomarker for head and neck squamous cell carcinoma (HNSCC) in human” was highlighted in a news release from News and communication service at OSU on April 28, 2009. This was later picked up by several national and international ad agencies.
Sandoval M was a 1st place winner at the poster/presentation contest, Celebrating Undergraduate Excellence (CUE) Symposium, Oregon State University, Corvallis, Oregon. (MA Sandoval, BR Sloat, Z Cui, Superior anti-tumor activity from a gemcitabine prodrug incorporated into nanoparticles)
Grants Received:
Maier C (co-investigator) Stevens F (co-investigator). Purchase of an Ion Mobility Time-of-Flight mass spectrometer. $455,000 from the National Center for Research Resources (NIH) with matching funds in the amount of $150,000 came from the Colleges of Pharmacy, Agriculture, and Science and from the Environmental Health Sciences Center and the OSU Research Office. This instrument is capable of separating ionized molecules in the gas phase based on size, shape and m/z.
College of Pharmacy Annual Rising Lecture; April 3 and 4, 2009
The College of Pharmacy held its annual research seminar in April. Students from all laboratories presented reports of research progress in podium and poster presentations.
Podium Presentations:
Andrew Hau (Ishmael Group)
Title: Exploring a role for LC8 in the assembly and trafficking of NMDA-type glutamate receptors
Stephen Hyter (Indra Group)
Title: Cooperative effects of keratinocytic RXR and CDK4 in melanoma metastasis
Heather Kuiper (Stevens Group)
Title: Quantitation of Mercapturic Acid Conjugates of 4-Hydroxynonenal and 4-Oxononenal Metabolites in Smokers and Non-smokers by Electrospray LC-MS/MS
Yi-Chen Lee (Leid Group)
Title: Expression of Ctip2 during early mouse development
Dong Li (Proteau Group)
Title: Synthesis of Coibamide A
Wanli Lu (Mahmud Group)
Title: Functional Analysis of the Pactamycin Biosynthetic Gene Cluster
Michael Sandoval (Cui Group)
Title: Gemcitabine Prodrug Incorporated into Nanoparticles has a Superior Anti-Tumor Activity
Brian Sloat (Cui Group)
Title: A Novel Lecithin-Based Nanoparticle as a Platform for Vaccine Delivery
Anand Venkataraman (Leid Group)
Title: In vivo role of Grasp
Nijaporn Yanasarn (Cui Group)
Title: Lecithin-Based Nanoparticles as a Potential Delivery System for Docetaxel
Zhixing Wang (Indra Group)
Title: Effects of Acute Solar UV Radiation on Mice Selectively Lacking Nuclear Receptor RXR in Epidermal Keratinocytes
Ling-juan Zhang (Leid Group)
Title: Molecular Mechanisms underling Ctip2-mediated transcriptional regulation in T cells
Poster Presentations:
Dehali Bandyopadhy (Allen Group)
Title: Review of the Impact of Ventilator Bundle Implementation to Prevent Ventilator-Associated Pneumonia (VAP) in the Intensive Care Setting
Adam Campbell (Kioussi Group)
Title: In vitro Studies of the Contractile Apparatus in Pitx2 Mutants
Claire Evangelista (Allen Group)
Title: Evaluation of comparative fluoroquinolone resistance selection in Salmonella enteritidis using an in vitro pharmacodynamic model.
Neal Goebel (Zabriskie Group)
Title: Preparation of Standards for the Analysis of Enduracidin Lipid Tail Biosynthesis
Stephen Hyter (Indra Group)
Title: Cooperative effects of RXR and CDK4 in melanomagenesis
Dr. Noer Kasanah (Zabriskie/Proteau/Mahmud Groups)
Title: Genomic Profiling, Taxonomy and Bioassay Based Screening of Indonesian Actinomycetes to Discover New Anti-Infective Agents
Dale F. Kraemer (Kraemer Group)
Title: Degree of Blood-Brain Barrier Disruption and Cumulative Total Dose Intensity in the Treatment of Primary Central Nervous System Lymphoma
Xiao Liu (Leid Group)
Title: Studying the function of Ctip2 by site-directed mutagenesis
Pham Loan (Christensen Group)
Title: Pharmacokinetics of Flunixin in African Elephants
Wanli Lu (Mahmud Group)
Title: Functional Analysis of the Pactamycin Biosynthetic Gene Cluster
Hsiao-Yen Ma (Kioussi Group)
Title: Transcription Factors Involved in Cardiac Development
Justyna Sikorska (McPhail Group)
Title: Cytotoxic Metabolites From Endemic South African Tunicates
Christopher Thornburg (McPhail Group)
Title: Biologically Active Depsipeptides from Red Sea Cyanobacteria
Anand Venkataraman (Leid Group)
Title: In vivo role of Grasp
Zhixing Wang (Indra Group)
Title: Effects of Acute Solar UV Radiation on Mice Selectively Lacking Nuclear Receptor RXR in Epidermal Keratinocytes
Dr. Jongtae Yang (Mahmud Group)
Title: Biosynthetic Studies of the Antifungal Antibiotic Validamycin A
Lingjuan Zhang (Leid Group)
Title: Proteomic identification of a novel COUP-TFI complex and its implication in TNFalpha-induced
apoptosis
Grants Received
Cherala G (PI), Munar M. Evaluation of renal and non-renal metabolism of daptomycin in cancer mice. Cubist Pharmaceuticals, Inc. January 2009. [Amount: $7,310].
Cherala G (PI), Allen G. Reaction Block Upgrade Kit, iQ5. OSU’s Research Equipment Reserve Fund Fall 2008-09 Award. February 2009. [Amount: $15,000].
Peer Reviewed Journal Publications
Hartung DM, Touchette D. Overview of clinical research design. Am J Health Syst Pharm. 2009 Feb 15;66(4):398-408.
Bubalo JS, Munar MY, Cherala G, Hayes-Lattin B, Maziarz R. Daptomycin pharmacokinetics and in adult oncology patients with neutropenic fever. Antimicrob Agents Chemother 2009;53(2):428-34 (Antimicrob Agents Chemother 2008 Nov 17 Epub ahead of print) Impact factor: 4.4
Williams CD. Not so choppy SEAS. J Clin Lipid 2009;3:11-13
Books Edited/Chapters Written
None
Other Publications
Ito MK. Maintaining Cardiovascular Health in Patients With Mixed Dyslipidemia: Optimizing the Management of Hypertriglyceridemia and Non-HDL Cholesterol. Journal of Managed Care Pharmacy. 2009; 15(1): S3-S8.
Research Presentations at Professional Meetings
None
Continuing Education Programs or Invited Presentations
Ito MK. “Vascular Effects of Plant Sterols” 2009 Annual Scientific Forum of the Pacific Lipid Association, Salt Lake City, UT – February 21, 2009.
Ito MK. “Lipid Regulating Drug Pharmacology” Masters in Lipidology Advanced Training and Board Review Course, Salt Lake City, UT – February 19, 2009
Ramirez S. "Finding a Safety Net Partner" presentation, February 12, 2009. Safety Net Conference, USC, Los Angeles, CA.
Ramirez S, Braeden N. "New Drugs 2008" presentation, February 21, 2009, Lane County CE, Eugene, OR.
Williams CD, Ito M. Hosted the 9th Portland Vascular Society meeting on January 13th. Seventeen physician and non-physician attendees from around the Portland and Vancouver metro area attended the program.
Awards, Honors, Appointments, Elections
Williams CD. Appointed for second year to the American Diabetes Association’s national guideline committee
Williams CD. Appointed to national consensus writing group on use of ASA for primary prevention in diabetes
