Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Department of Pharmaceutical Sciences,
July and August 2009
Department Activities:
Pharmaceutical Sciences hosted Dr. Chandrahas Sahajwalla, Deputy Director of the Division of Biopharmaceutics at the United States Food and Drug Administration. On Wednesday, August 26, he gave a two-part seminar entitled, How OCP Fits into Drug Development, and Review: Overview of Office of Clinical Pharmacology (OCP).
Travels and Professional Service:
DeLander G attended the AACP annual meeting in Boston, Massachusetts.
On July 20, Ishmael J met with members of the Pharmacology Division at the University of Bradford School of Pharmacy, in Yorkshire, England, to interview a future graduate student visitor.
Ganguli-Indra G. attended the Gordon Research Conference on Barrier Function of Mammalian Skin, August 8- 14, 2009, in Waterville Valley Resort, New Hampshire.
Mahmud T attended the 15th International Symposium on the Biology of Actinomycetes, August 20-August 25, 2009, in Shanghai, China.
Mahmud T attended the International Symposium of Chemical Biology, August 26-August 29, 2009, in Xiamen, China.
Invited Presentations:
Ganguli-Indra G. Function of regulatory protein Ctip2 during wound healing and in cancer. August 3, 2009. Oregon State University SMILE program, Corvallis, Oregon.
Indra A K. Nuclear Receptor Signaling in tumor micro-environment during melanoma formation. August 3, 2009. Oregon State University SMILE program, Corvallis, Oregon.
Indra A K. Dual role of COUP-TF-interacting protein 2 (CTIP2) in epidermal homeostasis and permeability barrier formation. August 8- 14, 2009. Hot Topic session at the Gordon Research Conference on Barrier Function of Mammalian Skin, Waterville Valley Resort, New Hampshire
Zabriskie M. Precursor Formation in the Biosynthesis of the Lipopeptide Enduracidin. Society for Industrial Microbiology Annual Meeting, Toronto, Ontario, Canada
Research Posters and Oral Presentations:
Mahmud T, Ito T, Roongsawang T, Shirasaka N, Lu W, Flatt PM, Kasanah N, Miranda C. Biosynthetic Studies of Pactamycin and Engineered Production of Pactamycin Analogs. August 20-25, 2009. The 15th International Symposium on the Biology of Actinomycetes, Shanghai, China (oral presentation).
Mahmud T. Biosynthetic Studies of C7N-aminocyclitol-containing Natural Products: A Progress Report. August 26-29, 2009. The International Symposium of Chemical Biology, Xiamen, China (oral presentation).
Li D; McPhail K L; Proteau PJ. Synthesis of Coibamide A: A Potent Antiproliferative Cyclic Depsipeptide from a Panamanian Marine Cyanobacterium. June 27-July 1, 2009. American Society of Pharmacognosy 50th Annual Meeting, Honolulu, Hawaii (poster).
Sorrels CM, Proteau PJ, Gerwick WH. Insights into the Chemistry and Biosynthesis of UV-Absorbing Natural Products from Cyanobacteria. June 27-July 1, 2009. American Society of Pharmacognosy 50th Annual Meeting, Honolulu, Hawaii (oral presentation).
Reed RL and Stevens JF. Glucosinolate degradation products in fermented meadowfoam seed meal and their herbicidal activities. August 8-12, 2009. 49th Annual Meeting of the Phytochemical Society of North America, Towson, Maryland (oral presentation).
Miranda CL and Stevens JF. Xanthohumol and related prenylated flavonoids from hops inhibit production of inflammatory mediators in activated monocytes and macrophages. August 8-12, 2009. 49th Annual Meeting of the Phytochemical Society of North America, Towson, Maryland (oral presentation).
Publications:
Fahmy S, Christensen JM, Ayres, J. Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine. Drug Development and Industrial Pharmacy. 2009, 35, 8: 1009-1021.
Ito T, Roongsawang N, Shirasaka N, Lu W, Flatt PM, Kasanah N, Miranda C,
Mahmud T. Deciphering Pactamycin Biosynthesis and Engineered Production of Pactamycin Analogues. ChemBioChem. 2009, 10: 2253-2265.
Sorrels CM, Proteau PJ, Gerwick WH. Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Appl. Environ. Microbiol. 2009, 75: 4861-4869.
Grants Received:
Mahmud T (PI). Design of Novel Antifungal and Insecticidal Agents Using Validoxylamine A as a Scaffold. Herman Frasch Foundation. $50,000, third installment, five year funding.
Yin X (PI), Zabriskie TM (co-investigator). Genetic and Chemical Approaches to Novel Lipid II Binding Peptide Antibiotics. National Institutes of Health (NIAID) (R01). August, 2008. $358,556. Third installment, four year funding.
Zabriskie TM (PI), McPhail K (co-investigator). Biodiscovery from Deep Sea Hydrothermal Vent Organisms. National Oceanic and Atmospheric Agency – Oceans and Human Health Initiative. $20,000 with a$20,000 match from the OSU Research Office.
Department of Pharmacy Practice,
January and February 2009
Grants Received
Cherala G (PI), Munar M. Evaluation of renal and non-renal metabolism of daptomycin in cancer mice. Cubist Pharmaceuticals, Inc. January 2009. [Amount: $7,310].
Cherala G (PI), Allen G. Reaction Block Upgrade Kit, iQ5. OSU’s Research Equipment Reserve Fund Fall 2008-09 Award. February 2009. [Amount: $15,000].
Peer Reviewed Journal Publications
Hartung DM, Touchette D. Overview of clinical research design. Am J Health Syst Pharm. 2009 Feb 15;66(4):398-408.
Bubalo JS, Munar MY, Cherala G, Hayes-Lattin B, Maziarz R. Daptomycin pharmacokinetics and in adult oncology patients with neutropenic fever. Antimicrob Agents Chemother 2009;53(2):428-34 (Antimicrob Agents Chemother 2008 Nov 17 Epub ahead of print) Impact factor: 4.4
Williams CD. Not so choppy SEAS. J Clin Lipid 2009;3:11-13
Books Edited/Chapters Written
None
Other Publications
Ito MK. Maintaining Cardiovascular Health in Patients With Mixed Dyslipidemia: Optimizing the Management of Hypertriglyceridemia and Non-HDL Cholesterol. Journal of Managed Care Pharmacy. 2009; 15(1): S3-S8.
Research Presentations at Professional Meetings
None
Continuing Education Programs or Invited Presentations
Ito MK. “Vascular Effects of Plant Sterols” 2009 Annual Scientific Forum of the Pacific Lipid Association, Salt Lake City, UT – February 21, 2009.
Ito MK. “Lipid Regulating Drug Pharmacology” Masters in Lipidology Advanced Training and Board Review Course, Salt Lake City, UT – February 19, 2009
Ramirez S. "Finding a Safety Net Partner" presentation, February 12, 2009. Safety Net Conference, USC, Los Angeles, CA.
Ramirez S, Braeden N. "New Drugs 2008" presentation, February 21, 2009, Lane County CE, Eugene, OR.
Williams CD, Ito M. Hosted the 9th Portland Vascular Society meeting on January 13th. Seventeen physician and non-physician attendees from around the Portland and Vancouver metro area attended the program.
Awards, Honors, Appointments, Elections
Williams CD. Appointed for second year to the American Diabetes Association’s national guideline committee
Williams CD. Appointed to national consensus writing group on use of ASA for primary prevention in diabetes
