Compound Libraries

 

THE OREGON COLLECTION (This collection is currently being expanded)

The Oregon collection is made up of hundreds of novel, locally-sourced, natural and synthetic chemical compounds contributed by chemists and scientists from the four major Oregon research universities—Oregon State University, Portland State University, Portland Veterans Affairs Medical Center/Oregon Health and Science University, and University of Oregon. Oregon university-based researchers have provided their compounds so that they may be assayed for their ability to kill microorganisms that cause infectious diseases. 

 

Chembridge: DIVERSet

http://www.chembridge.com/datasheets/DIVERSet.pdf

DIVERSet™ - A "universally" diverse collection of50,000 drug-like small molecules. The chemical library is rationally selected based on 3D pharmacophore analysis to cover the broadest part of biologically relevant pharmacophore diversity space. A highly recognized and proven primary screening tool for a wide range of both validated and new biological targets.

 

OSU/CoP Small Molecule Library 

This approximately 246,000 compound library was purchased from SIGA Technologies in 2014 and is made up of compounds from the ChemBridge DIVERSet-CL library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv. 

 

MicroSource Discovery: Spectrum Collection

http://msdiscovery.com/spectrum.html

The Spectrum Collection- The 2000 compounds in the SPECTRUM Collection were selected by medicinal chemists and biologists so as to provide a wide range of biological activities and structural diversity for screening programs with special emphasis on the de-novo assays emerging today. Such content provides the opportunity to evaluate drugs and biochemical tools with known biological profiles and, at the same time, explore the potential of novel structural and topographical diversity manifest in pure natural products. Each compound has a minimum of 95% purity.  Approved Drug Components (50% or ~1000 compounds)Natural Products (30% or ~600 compounds), Other Bioactive Components (20% or 400 compounds).

 

Maybridge: HitFinder Collection

http://www.maybridge.com/portal/alias__Rainbow/lang__en/tabID__229/DesktopDefault.aspx

 The 14,400 compound HitFinder collection of compounds is a subset of compounds maximized for structural diversity. The compounds are provided in microtiter plates, 1 umole each compound in dry film, 80 compounds per plate, first and last columns empty, 180 plates. 

 

Natural Products Discovery Institute (NPDI) Collection

http://www.npdi-us.org/collection.html

 The NPDI collection contains 10,000 extracts from a wide variety microbial and plant species, which were formerly owned by Merck.  

 

National Institutes of Health Clinical Collection (NIHCC)

The NIH Clinical Collection is a plated array of small molecules that have a history of use in human clinical trials. The collection was assembled through the Molecular Libraries and Imaging Initiative as part of its mission to enable the use of compound screens in biomedical research.

446 compounds