John Block

Emeritus Appointment
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Office: 541-737-5779

Pharmacy Building

Pharmacy Building 115B

1601 SW Jefferson Avenue

1601 SW Jefferson Avenue
Corvallis, OR 97331
Credentials: 
Stanford University, N.I.H. Special Postdoctoral Fellow and Visiting Scholar, 1972-73 University of Wisconsin, Ph.D., 1966 Washington State University, M.S., 1963 B.Phar., B.S., 1961

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At OSU
Affiliated with: 
Pharmacy Professnl Instr
Faculty Type: 
Emeritus
Research/Career Interests: 

John Block’s research into quantitative structure activity relationships (QSAR) seeks to describe chemical models mathematically, defining equations that will predict or explain biological responses. He has investigated the use of chemical graph theory in QSAR studies and the application of multivariate statistics to search for underlying relationships among biologically active molecules. One collaborative project looks at the current controversy over the action of general anesthesia and dispersion interaction with receptors in the nervous system.

Selected Publications

Block JH. Physicochemical Properties in Relation to Biological Action. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed. Philadelphia: Lippincott-Raven; Chapter 2.

Block JH, Antimalarias. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed.Philadelphia: Lippincott-Raven; Chapter 11.
  
Cutler SJ, Block JH. Drug Metabolism. In: Delgado JN, Block JH, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th ed. Philadelphia: Lippincott-Raven; Chapter 4. 
  
Block JH. Selective Toxicity. In: Abraham D, ed. Burger’s Medicinal Chemistry and Drug Discovery, 6th ed., Vol 5. New York: John Wiley & Sons; 2003:249-280. 
  
Block JH. Vitamins. In: Abraham D, ed. Burger’s Medicinal Chemistry and Drug Discovery, 6th ed., Vol. 4. New York: John Wiley & Sons; 2003:359-420. 
  
Block JH, Yu Y, King JW, Verloop A. A Quantitative Structure Activity Relationships Study of Antiinfectives Based on the Nalidixic Acid Structure. In: Magee PS, Henry DR, Block JH, eds. Probing Bioactive Mechanisms by Modeling and Statistical Inference. ACS Symposium Series #413, Washington, D.C.: ACS Books; 1989:301-350. (This chapter is a retrospective study that isolated the important structural elements and determined their effectiveness from among 100 synthesized compounds.)
  
Chiou CT, Block JH. Parameters affecting the partitin coefficients of organic compounds in solvent-water and lipid-water systems. In: Dunn WJ, Block JH, Pearlman RS, eds. Partition Coefficient: Determination and Estimation. New York: Pergamon Press; 1986:37-60.

J. H. Block and D. R. Henry, Evaluation of Descriptors and Classification Schemes to Predict Cytochrome Substrates in Terms of Chemical Information, J. Comp. Aided Mol. Design, 22, 385-392, 2008

History

Member for
3 years 11 months