Dr. Filtz's general research interest is in signal transduction. As a pharmacologist, her lab has studied post-translational regulation of signaling proteins and transcription factors associated with T cell leukemias and atrial fibrillation, and the effects of natural products on heart cells.
The Indra laboratory is investigating the mechanisms underlying the crosstalk between skin-cells and role of microenvironment in atopic-dermatitis, vitiligo, tumor-heterogeneity and in metastatic melanoma. We discovered different factors that regulate UV-induced melanocyte/epidermal stem-cell survival, proliferation and migration. The anti-cancer, anti-oxidant, anti-inflammatory and anti-ageing effects of bioactive natural compounds are further studied.
We are studying tissue regeneration and wound-healing using mice-models and 3D-human bioprinted skin. We utilize biodegradable nanofibers loaded with growth-factors, anti-microbial peptides and exosomes for efficient healing of chronic wounds in diabetes and hypoxia. Anti-cancer, anti-aging and anti-oxidant effects of bioactive compounds from hemp, hops and meadowfoam are being investigated.