Andrey Morgun
Research/Career Interests
Systems Pharmacology and Biomedicine is an emerging area of research aiming to improve drug discovery and make treatment for each patient highly individualized. The rationale behind is that the therapeutic decisions for each patient will be based on the results of molecular tests that will provide credible, quantitative information of efficacy and adverse effects of each available drug for a particular patient.
Our lab is focusing on health problems in which an unbalanced interaction between immune, other host systems and different microbes leads to pathology. Those diseases range from immunodeficiency- associated enteropathy to cervical cancer and acute rejection of heart and renal transplants. We employ multiple large-scale quantitative approaches (also called “omics” (http://en.wikipedia.org/wiki/Omics) to generate the data and use this data to make predictive statistical models and networks that allow us to address three major topics:
- Discover new or repurpose old drugs
- Generate diagnostic/predictive “omics” signatures for personalized medicine
- Validate experimental animal models for human research using “omics” approaches.
Career Links
Credentials
National Instutitute of Allergy and Infectious Diseases (NIAID), NIH - Post-doctoral Traning, 2005-2011 Federal University of Sao Paulo, Brazil - Ph.D., 2002 Kharkiv Medical University, Ukraine - MD, 1995
1601 SW Jefferson Avenue
Pharmacy Building 403
97331 OR
United States
Our efforts are focused on the understanding how the interplay between host and microbiota contributes to pathogenesis and treatment of diseases such as type 2 diabetes, NASH, IBD, immunodeficiency, and cancer. This is a highly collaborative effort involving advanced causality inference and network analyses of multi-omics data coupled with gnotobiotic animal models, observational and interventional (i.e. clinical trials) studies in patient populations.