Our research utilizes an interdisciplinary approach toward the development of effective nanomaterials-based imaging and therapeutic agents, particularly for cancer, endometriosis, and placenta-related diseases. This includes the development of photo-theranostic agents for use in image-guided therapies. The main objective is to assist with accurate early diagnosis/visualization of tissue of interest using innovative nano-imaging probes, with subsequent immediate treatment.
Our research focuses on novel nanomedicines for imaging and treatment of cancer, endometriosis, and other diseases. We are developing multifunctional nanoplatforms for fluorescence-guided surgery, intraoperative phototherapy, magnetic hyperthermia and gene therapy. Our primary objective, which is currently funded by four NIH grants, is to translate the developed nanoplatforms into the clinic.
Our laboratory investigates the interface of material science and biology to develop novel drug delivery and molecular imaging platforms. This interdisciplinary research leverages advanced chemistry techniques, bioengineering, and strong clinical collaborations to develop experimental therapeutics and new imaging modalities. In particular, this work exploits the unique capabilities of nanomaterials to improve the efficacy of conventional cancer treatments.
Sahay lab is developing state of the art lipid-based nanoparticles for effective delivery of mRNA based vaccines and therapeutics. We design, characterize, and formulate nanoparticles and study their intracellular delivery mechanisms. Currently, our lipid nanoparticles are deployed to deliver genes/genome editors for the treatment of CF, retinal degeneration and COVID-19.