Faculty

Gary DeLander's research centers around pain — the way pain signals are transmitted in the body, the means the body uses to inhibit pain signals and how various drugs work in the body to inhibit pain. His research efforts deal almost exclusively with these topics as they relate to the spinal cord and its role in the modification of pain. He has concentrated on the role of opioids and adenosine as endogenous inhibitors of pain.

Selected Publications

Stiller C-O, DeLander GE, Fastbom J, Brodin E. The Adenosine Analogue R-PIA Increases the Affinity of the SP-Receptor in the Dorsal Horn of the Rat Spinal Cord. Research Communications in Pharmacology and Toxicology. 1997;2:209-217.

DeLander GE, Schott E, Brodin E, Fredholm BB. Temporal Changes in Spinal Cord Expression of mRNA for Substance P, Dynorphin and Enkephalin in a Model of Chronic Pain. Acta Physiologica Scandinavica. 1997;161:517-525.

DeLander GE, Schott E, Brodin E, Fredholm BB. Spinal Expression of mRNA for Immediate Early Genes in a Model of Chronic Pain.Acta Physiologica Scandinavica. 1997;16:509-516.

Choi H, Murray TF, DeLander GE, Schmidt WK, Aldrich JV. Synthesis and Opioid Activity of [D-Pro10] Dynorphin A-(1-11) Analogues with N-Terminal Alkyl Substitution. Journal of Medicinal Chemistry. 1997;40(17):2733-2739.

Arttamangkul S, Ishmael JE, Murray TF, Grandy DK, DeLander GE, Kieffer BL, Aldrich JV. Synthesis and Opioid Activity of Conformationally Constrained Dynorphin A Analogues. 2. Conformational Constraint in the "Address" Sequence. Journal of Medicinal Chemistry. 1997;40(8):1211-1218.

Kulkarni SN, Choi H, Murray TF, DeLander GE, Aldrich JV. The Use of the Message-Address Concept in the Design of Potential Antagonists Based on Dynorphin A. In: Kaumaya TP and Hodges RS, eds. Peptides: Chemistry and Biology. West Midlands, England: Mayflower Scientific Ltd.; 1996:655-656.

Keil GJ, DeLander GE. Altered Sensory Behaviors in Mice Following Manipulation of Endrogenous Spinal Adenosine Neurotransmission. European Journal of Pharmacology. 1996;312:7-14.

Keil GJ, DeLander GE. Time-Dependent Antinociceptive Interactions Between Opioids and Nucleoside Transport Inhibitors. Journal of Pharmacology and Experimental Therapeutics. 1995;274:1387-1392.

Arttamangkul S, Murray TF, DeLander GE, Aldrich JV. Synthesis and Opioid Activity of Conformationally Constrained Dynorhin A Analogues. 1. Conformational Constraint in the "Message" Sequence. Journal of Medical Chemistry. 1995;38:2410-2417.

Arttamangkul S, Murray TF, DeLander GE, Aldrich JV. Synthesis and Opioid Activity of Conformationally Constrained Dynorhin A Analogues. Regulatory Peptides. 1994;54:13-14.

Keil GJ, DeLander GE. Adenosine Kinase and Adenosine Deaminase Inhibition Modulate Spinal Adenosine- and Opioid Agonist-Induced Antinociception in Mice. European Journal of Pharmacology. 1994;271:37-46.

DeLander GE, Keil GJ. Antinociception Induced by Intrathecal Coadministration of Selective Adenosine Receptor and Selective Opioid Receptor Agonists in Mice. Journal of Pharmacology and Experimental Therapeutics. 1994;268:943-951.

Snyder KR, Murray TF, DeLander GE, Aldrich JV. Synthesis and Opioid Activity of Dynorphin A-(1-13)NH2 Analogues Containing cis- and trans-4-Aminocyclohexanecarboxylic Acid. Journal of Medicinal Chemistry. 1993;36:1100-1103.

DeLander GE, Mosberg HI, Porreca F. Involvement of Adenosine in Antinociception Produced by Spinal or Supraspinal Receptor Selective Opioid Agonists: Dissociation from Gastrointestinal Effects of Mice. Journal of Pharmacology and Experimental Therapeutics. 1992;263:1097-1104.

Keil GJ, DeLander GE. Spinally Mediated Antinociception is Induced in Mice by an Adenosine Kinase-, but not Adenosine Deaminase-, Inhibitor. Pharmaco. Lett. 1992;51(19):171-176.

DeLander GE, Wahl JJ. Descending Systems Activated by Morphine (I.C.V.) Inhibit Kainic Acid (I.T.)-Induced Behavior.Pharmacology, Biochemistry and Behavior. 1991;39:155-159.

DeLander GE, Wahl JJ. Morphine (I.C.V.) Activates Spinal Systems to Inhibit Behavior Induced by Putative Pain Neurotransmitters.Journal of Pharmacology and Experimental Therapeutics. 1989;251:1090-1095.

DeLander GE, Wahl JJ. In Vivo Characterization of PCP/Sigma Agonist-Mediated Inhibition of Nociception Induced by NMDA and Substance P. European Journal of Pharmacology. 1989;149:149-156.

DeLander GE, Hopkins CJ. Interdependence of Spinal Adenosinergic, Serotonergic and Noradrenergic Systems Mediating Antinociception. Neuropharmacology. 1987;26:1791-1794.

DeLander GE, Hopkins CJ. Spinal Adenosine Modulates Descending Antinocicpetive Pathways Stimulated by Morphine. Journal of Pharmacology and Experimental Therapeutics. 1986;239:88-93.