Our efforts are focused on the understanding how the interplay between host and microbiota contributes to pathogenesis and treatment of diseases such as type 2 diabetes, NASH, IBD, immunodeficiency, and cancer. This is a highly collaborative effort involving advanced causality inference and network analyses of multi-omics data coupled with gnotobiotic animal models, observational and interventional (i.e. clinical trials) studies in patient populations.
Sahay lab is developing state of the art lipid-based nanoparticles for effective delivery of mRNA based vaccines and therapeutics. We design, characterize, and formulate nanoparticles and study their intracellular delivery mechanisms. Currently, our lipid nanoparticles are deployed to deliver genes/genome editors for the treatment of CF, retinal degeneration and COVID-19.