2022
Su Y, Sharma NS, John JV, Ganguli-Indra G, Indra AK, Gombart AF, Xie J. Engineered Exosomes Containing Cathelicidin/LL-37 Exhibit Multiple Biological Functions. Adv Healthc Mater. 2022 Aug 5:e2200849. doi: 10.1002/adhm.202200849. PMID: 35930707.
Bhattacharya N, Indra AK, Ganguli-Indra G. Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo. Cells. 2022 Jul 3;11(13):2106. doi: 10.3390/cells11132106. PMID: 35805190; PMCID: PMC9265695.
Carpenter EL, Becker AL, Indra AK. NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation. Cancers (Basel). 2022 Mar 16;14(6):1531. doi: 10.3390/cancers14061531. PMID: 35326683; PMCID: PMC8946769.
Stanton, DN., Ganguli-Indra,G., Indra, AK. and Karande, P. Bioengineered Efficacy Models of Skin Disease: Advances in the Last 10 Years Pharmaceutics. 2022, 14(2), 319; https://doi.org/10.3390/pharmaceutics. LINK
Su,Y., Ganguli-Indra, G., Bhattacharya, N.,.Logan, I.E., Indra,A.K., Gombart, A.F., Wong, S.L. and Xie, J. Codelivery of 1α,25-Dihydroxyvitamin D3 and CYP24A1 Inhibitor VID400 by Nanofiber Dressings Promotes Endogenous Antimicrobial Peptide LL-37 Induction. https://doi.org/10.1021/acs.molpharmaceut.1c00944 LINK
Carpenter EL, Wyant MB, Indra A, Ito S, Wakamatsu K, Merrill GF, Moos PJ, Cassidy PB, Leachman SA, Ganguli-Indra G, Indra AK. Thioredoxin Reductase 1 Modulates Pigmentation and Photobiology of Murine Melanocytes in vivo. J Invest Dermatol. 2022 Jan 11:S0022-202X(21)02605-1. doi: 10.1016/j.jid.2021.11.030. PMID: 35031135 LINK
2021
Bhattacharya N, Ganguli-Indra G, Indra AK. CTIP2 and lipid metabolism: regulation in skin development and associated diseases. Expert Rev Proteomics. 2021 Nov;18(11):1009-1017. doi: 10.1080/14789450.2021 .2003707. Epub 2021 Nov 17. PMID: 34739354 LINK
Becker AL, Carpenter EL, Slominski AT, Indra AK. The Role of the Vitamin D Receptor in the Pathogenesis, Prognosis, and Treatment of Cutaneous Melanoma. Front Oncol. 2021 Oct 6;11:743667. doi: 10.3389/fonc.2021.743667. PMID: 34692525; PMCID: PMC8526885.
Noviany, N, Samadi, A, Carpenter, EL, Abugrain, M E, Hadi, S, Purwitasari, N, Indra, G, Indra, A, Mahmud, T. Structural revision of sesbagrandiflorains A and B, and synthesis and biological evaluation of 6-methoxy-2-arylbenzofuran derivatives. Journal of Natural MedicinesDOI: 10.1007/S11418-020-01445-2 LINK
2020
Lowry MB, Guo C, Zhang Y, Fantacone ML, Logan IE, Campbell Y, Zhang W, Le M, Indra AK, Ganguli-Indra G, Xie J, Gallo RL, Koeffler HP, Gombart AF. A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression. J Steroid Biochem Mol Biol. 2020 Apr;198:105552. doi: 10.1016/j.jsbmb.2019.105552. Epub 2019 Nov 26. PMID: 31783153 LINK
Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kraemer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, Stemwedel CE, Kulesz-Martin MF. Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting. J Invest Dermatol. 2020 Feb;140(2):269-274. doi: 10.1016/j.jid.2019.03.1164. Epub 2019 Jul 23. PMID: 31348921; PMCID: PMC6981008.
2019
Pinkham, K, Park, DJ, Hashemiaghdam, A, Kirov, AB, Adam, I, Rosiak, K, da Hora, CC, Teng, J, Cheah, PS, Carvalho, L, Ganguli-Indra, G, Kelly, A, Indra, AK, Badr, CE. Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells. Apr 2019 in Stem Cell Reports DOI: 10.1016/J.STEMCR.2019.02.012 LINK
Bhattacharya N, Indra AK, Ganguli-Indra G. Healing of Full-Thickness Murine Skin Wounds Containing Nanofibers Using Splints for Efficient Re-epithelialization and to Avoid Contracture. Methods Mol Biol. LINK 2020;2155:115-123. doi: 10.1007/978-1-0716-0655-1_10. PMID: 32474872
Carpenter EL, Chagani S, Nelson D, Cassidy PB, Laws M, Ganguli-Indra G, Indra AK. Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAFV600E mutation bearing metastatic melanoma cells. Mol Carcinog. 2019 Sep;58(9):1680-1690. doi: 10.1002/mc.23068. Epub 2019 Jun 18. PMID: 31211467LINK
Bhattacharya N, Ganguli-Indra G, Indra AK. Transcriptional control and transcriptomic analysis of lipid metabolism in skin barrier formation and atopic dermatitis (AD). Expert Rev Proteomics. 2019 Aug;16(8):627-645. doi: 10.1080/14789450.2019.1646128. Epub 2019 Aug 14. PMID: 31322970 LINK
Bhattacharya N, Sato WJ, Kelly A, Ganguli-Indra G, Indra AK. Epidermal Lipids: Key Mediators of Atopic Dermatitis Pathogenesis. Trends Mol Med. 2019 Jun;25(6):551-562. doi: 10.1016/j.molmed.2019.04.001. Epub 2019 May 1. PMID: 31054869 LINK
2018
Filipp FV, Birlea S, Bosenberg MW, Brash D, Cassidy PB, Chen S, D'Orazio JA, Fujita M, Goh BK, Herlyn M, Indra AK, Larue L, Leachman SA, Le Poole C, Liu-Smith F, Manga P, Montoliu L, Norris DA, Shellman Y, Smalley KSM, Spritz RA, Sturm RA, Swetter SM, Terzian T, Wakamatsu K, Weber JS, Box NF. (2018) Frontiers in pigment cell and melanoma research. Pigment Cell Melanoma Res. 2018 Nov; 31(6):728-735. doi: 10.1111/pcmr.12728.
Jiang J, Zhang Y, Indra AK, Ganguli-Indra G, Le MN, Wang H, Hollins RR, Reilly DA, Carlson MA, Gallo RL, Gombart AF, Xie J. (2018) 1α,25-dihydroxyvitamin D3-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression. (2018) Nanomedicine (Lond.). 2018 Jun; 13(12):1417-1432. doi: 10.2217/nnm-2018-0011.
Carpenter EL, Le MN, Miranda CL, Reed RL, Stevens JF, Indra AK, Ganguli-Indra G. (2018) Photoprotective properties of isothiocyanate and nitrile glucosinolate derivatives from meadowfoam (Limnanthes alba) against UVB irradiation in human skin equivalent. Front Pharmacol. 2018 May 15; 9:477. doi: 10.3389/fphar.2018.00477.
Brumsted CJ, Carpenter EL, Indra AK, Mahmud T. (2018) Asymmetric synthesis and biological activities of pactamycin-inspired aminocyclopentitols. Org Lett. 2018 Jan 19; 20(2):397-400. doi: 10.1021/acs.orglett.7b03681.
2017
Chagani S, Wang R, Carpenter EL, Löhr CV, Ganguli-Indra G, Indra AK. Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas. BMC Cancer. 2017 Nov 9; 17(1):736. doi: 10.1186/s12885-017-3714-6.
Li S, Teegarden A, Bauer EM, Choi J, Messaddeq N, Hendrix DA, Ganguli-Indra G, Leid M, Indra AK. Transcription factor CTIP1/BCL11A regulates epidermal differentiation and lipid metabolism during skin development. Sci Rep. 2017 Oct 18; 7(1):13427. doi: 10.1038/s41598-017-13347-7.
Kulkarni NN, Adase CA, Zhang LJ, Borkowski AW, Li F, Sanford JA, Coleman DJ, Aguilera C, Indra AK, Gallo RL. IL-1 receptor-knockout mice develop epidermal cysts and show an altered innate immune response after exposure to UVB radiation. J Invest Dermatol. 2017 Nov; 137(11):2417-2426. doi: 10.1016/j.jid.2017.07.814.
Bhattacharya S, Li S, Wheeler H, Wang R, Lohr CV, Leid M, Ganguli-Indra G, Indra AK. Ablation of CTIP2/BCL11B in adult epidermis enhances TPA/UV-induced proliferation and increases susceptibility to DMBA/TPA-induced epidermal carcinogenesis. J Invest Dermatol. 2017 Jul; 137(7):1594-1598. doi: 10.1016/j.jid.2017.02.971.
Li S, Villarreal M, Stewart S, Choi J, Ganguli-Indra G, Babineau DC, Philpot C, David G, Yoshida T, Boguniewicz M, Hanifin JM, Beck LA, Leung DY, Simpson EL, Indra AK. Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in atopic dermatitis. Br J Dermatol. 2017 Oct; 177(4):125-127. doi: 10.1111/bjd.15409.
2016
Chagani S, Kyryachenko S, Yamamoto Y, Kato S, Ganguli-Indra G, Indra AK. In vivo role of vitamin D receptor signaling in UVB-induced DNA damage and melanocyte homeostasis. J Invest Dermatol. 2016 Oct; 136(10):2108-2111. doi: 10.1016/j.jid.2016.06.004.
Li S, Ganguli-Indra G, Indra AK. Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans. Expert Rev Proteomics. 2016 May; 13(5):451-456. doi: 10.1080/14789450.2016.1177462.
Serrill JD, Wan X, Hau AM, Jang HS, Coleman DJ, Indra AK, Alani AW, McPhail KL, Ishmael JE. Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenographs. Invest New Drugs. 2016 Feb; 34(1):24-40. doi: 10.1007/s10637-015-0303-x.
2015
Doddapaneni BS, Kyryachenko S, Chagani SE, Alany RG, Rao DA, Indra AK, Alani AWG. A three-drug nanoscale drug delivery system designed for preferential lymphatic uptake for the treatment of metastatic melanoma. J Control Relase. 2015 Dec; 220(pt A):503-514. doi: 10.1016/j.jconrel.2015.11.013.
Ummadi JG, Joshi VS, Gupta PR, Indra AK, Koley D. Single-cell migration as studied by scanning electrochemical microscopy. Anal Methods. 2015 Oct 21; 7(20):8826-8831.
Bhattacharya S, Wheeler H, Leid M, Ganguli-Indra G, Indra AK. Transcription factor CTIP2 maintains hair follicle stem cell pool and contributes to altered expression of LHX2 and NFATC1. J Invest Dermatol. 2015 Nov; 135(11):2593-2602. doi: 10.1038/jid.2015.281.
Guha G, Lu W, Li S, Liang X, Kulesz-Martin MF, Mahmud T, Indra AK, Ganguli-Indra G. Novel pactamycin analogs induce p53 dependent cell-cycle arrest at S-phase in human head and neck squamous cell carcinoma (HNSCC) cells. PLoS One. 2015 May 4; 10(5):e0125322. doi: 10.1371/journal.pone.0125322.
Coleman DJ, Chagani S, Hyter S, Sherman AM, Löhr CV, Liang X, Ganguli-Indra G, Indra AK. Loss of keratinocytic RXRα combined with activated CDK4 or oncogenic NRAS generates UVB-induced melanomas via loss of p53 and PTEN in tumor microenvironment. Mol Cancer Res. 2015 Jan; 13(1):186-196. doi: 10.1158/1541-7786.MCR-14-0164.
2014
Coleman DJ, Garcia G, Hyter S, Jang HS, Chagani S, Liang X, Larue L, Ganguli-Indra G, Indra AK. Retinoid-X-receptors (α/β) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV radiation. PLoS Genet. 2014 May 8; 10(5):e1004321. doi: 10.1371/journal.pgen.1004321.
Venkataraman A, Coleman DJ, Nevrivy DJ, Long T, Kioussi C, Indra AK, Leid M. GRP1-associated scaffold protein regulates skin homeostasis after ultraviolet irradiation. Photochem Photobiol Sci. 2014 Mar; 13(3):531-540. doi: 10.1039/c3pp50351h.
2013
Indra AK. Epidermal TSLP: a trigger factor for pathogenesis of atopic dermatitis. Expert Rev Proteomics. 2013 Aug; 10(4):309-311. doi: 10.1586/14789450.2013.814881.
Hyter S, Indra AK. Nuclear hormone receptor functions in keratinocyte and melanocyte homeostasis, epidermal carcinogenesis and melanomagenesis. FEBS Lett. 2013 Mar 18; 587(6):529-541. doi: 10.1016/j.febslet.2013.01.041.
Hyter S, Coleman DJ, Ganguli-Indra G, Merrill GF, Ma S, Yanagisawa M, Indra AK. Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis. Pigment Cell Melanoma Res. 2013 Mar; 26(2):247-258. doi: 10.1111/pcmr.12063.
Wang Z, Kirkwood JS, Taylor AW, Stevens JF, Leid M, Ganguli-Indra G, Indra AK. Transcription factor CTIP2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol. 2013 Mar; 133(3):668-676. doi: 10.1038/jid.2012.358.
2012
Wang Z, Zhang LJ, Guha G, Li S, Kyrylkova K, Kioussi C, Leid M, Ganguli-Indra G, Indra AK. Selective ablation of CTIP2/BCL11B in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice. PLoS One. 2012; 7(12):e51262. doi: 10.1371/journal.pone.0051262.
Zhang LJ, Bhattacharya S, Leid M, Ganguli-Indra G, Indra AK. CTIP2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling. J Cell Sci. 2012 Dec 1; 125(pt 23):5733-5744. doi: 10.1242/jcs.108969.
Liang X, Bhattacharya S, Bajaj G, Guha G, Wang Z, Jang HS, Leid M, Indra AK, Ganguli-Indra G. Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking CTIP2 in epidermis. PLoS One. 2012; 7(2):e29999. doi: 10.1371/journal.pone.0029999.
Ocadiz-Delgado R, Castañeda-Saucedo E, Indra AK, Hernandez-Pando R, Flores-Guizar P, Cruz-Colin JL, Recillas-Targa F, Perez-Ishiwara G, Covarrubias L, Gariglio P. RXRα deletion and E6E7 oncogene expression are sufficient to induce cervical malignant lesions in vivo. Cancer Lett. 2012 Apr 28; 317(2):226-236. doi: 10.1016/j.canlet.2011.11.031.
2011
Indra AK, Leid M. Epidermal permeability barrier measurement in mammalian skin. Methods Mol Bio. 2011; 762:73-81. doi: 10.1007/978-1-61779-191-8_4.
Wang Z, Coleman DJ, Bajaj G, Liang X, Ganguli-Indra G, Indra AK. RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes. J Invest Dermatol. 2011 Jan; 131(1):177-187. doi: 10.1038/jid.2010.290.
2010
Hyter S, Bajaj G, Liang X, Barbacid M, Ganguli-Indra G, Indra AK. Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of CDK4-activated invasive melanomas. Pigment Cell Melanoma Res. 2010 Oct; 23(5):635-648. doi: 10.1111/j.1755-148X.2010.00732.x.
2009
Ganguli-Indra G, Wasylyk C, Liang X, Millon R, Leid M, Wasylyk B, Abecassis J, Indra AK. CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS One. 2009; 4(4):e5367. doi: 10.1371/journal.pone.0005367.
Ganguli-Indra G, Liang X, Hyter S, Leid M, Hanifin J, Indra AK. Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin. Exp Dermatol. 2009 Nov; 18(11):994-996. doi: 10.1111/j.1600-0625.2009.00876.x.
Golonzhka O, Liang X, Messaddeq N, Bornert JM, Campbell AL, Metzger D, Chambon P, Ganguli-Indra G, Leid M, Indra AK. Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J Invest Dermatol. 2009 Jun; 129(6):1459-1470. doi: 10.1038/jid.2008.392.
2008
Ocadiz-Delgado R, Castaneda-Saucedo E, Indra AK, Hernandez-Pando R, Gariglio P. Impaired cervical homeostasis upon selective ablation of RXRalpha in epithelial cells. Gensis. 2008 Jan; 46(1):19-28. doi: 10.1002/dvg.20357.
2007
Golonzhka O, Leid M, Indra G, Indra AK. Expression of COUP-TF-interacting protein 2 (CTIP2) in mouse skin during development and in adulthood. Gene Expr Patterns. 2007 Aug; 7(7):754-760.
Fadloun A, Kobi D, Pointud JC, Indra AK, Teletin M, Bole-Feysot C, Testoni B, Mantovani R, Metzger D, Mengus G, Davidson I. The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis. Development. 2007 Aug; 134(16):2947-2958.
Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P. Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1250-1260.
2005
Indra AK, Dupé V, Bornert JM, Messaddeq N, Yaniv M, Mark M, Chambon P, Metzger D. Temporarily controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier function. Development. 2005 Oct; 132(20)4533-4544.
Indra AK, Mohan WS 2nd, Frontini M, Scheer E, Messaddeq N, Metzger D, Tora L. TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis. Dev Biol. 2005 Sep 1; 285(1):28-37.
2003
Metzger D, Indra AK, Li M, Chapellier B, Calleja C, Ghyselinck NB, Chambon P. Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. Methods Enzymol. 2003; 364:379-408.
2000
Indra AK, Li M, Brocard J, Warot X, Bornert JM, Gérard C, Messaddeq N, Chambon P, Metzger D. Targeted somatic mutagenesis in mouse epidermis. Horm Res. 2000; 54(5-6): 296-300.
Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P. Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature. 2000 Oct 5; 407(6804):633-636.
1999
Indra AK, Warot X, Brocard J, Bornert JM, Xiao JH, Chambon P, Metzger D. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and CRE-ER(T2) recombinases. Nucleic Acid Res. 1999 Nov 15; 27(22):4324-4327.