Gaurav Sahay

Associate Professor

Office: 503-346-4698

Research Highlights: 

Sahay lab is developing state of the art lipid-based nanoparticles for effective delivery of mRNA based vaccines and therapeutics. We design, characterize, and formulate nanoparticles and study their intracellular delivery mechanisms. Currently, our lipid nanoparticles are deployed to deliver genes/genome editors for the treatment of CF, retinal degeneration and COVID-19.  

Profile Field Tabs

Affiliated with: 
Pharmacy Professnl Instr
Portland - OHSU
Faculty Type: 
Pharmaceutical Sciences
Research/Career Interests: 

Gaurav Sahay is an Associate Professor in the Department of Pharmaceutical Sciences, College of Pharmacy at Oregon State University. Dr. Sahay’s lab is developing novel nanotechnology-based platforms including lipid-based nanoparticles for effective delivery of messenger RNA therapeutics for treatment of cystic fibrosis, retinal degeneration and against SARS-CoV2. He has done pioneering work to dissect the intracellular transport essential for nucleic acid delivery to the cytosol and developed methods to overcome endosomal barriers. He has more than 48-peer-reviewed publications in top tier journals including Science Advances, Nature, Nature Communications, Nature Biotechnology, Nature Nanotechnology, Journal of Controlled Release, Nano Letters etc. He is the winner of a 2013 American Association of Pharmaceutical Scientists (AAPS) Postdoctoral Fellow Award, the 2015 Controlled Release Society (CRS) T. Nagai Award, a 2016 American Association of Colleges of Pharmacy (AACP) New Investigator Award, a 2019 Oregon Health & Sciences University (OHSU) Distinguished Faculty Senate Award for Collaboration, 2020 Phi Kappa Phi OSU Emerging Scholar Award and 2020 CMBE Young Innovator Award. He serves as the Principal Investigator on awards funded through the National Institutes of Health, Cystic Fibrosis Foundation, and in the past through Moderna Therapeutics, MRF New Investigator and OSU. He serves as a consultant and scientific advisory board member to several biotech and venture capital firms. He was the Chair of the 2018 NanoMedicine and Drug Delivery Symposium (NanoDDS, Portland, OR). Dr. Sahay completed his postdoctoral research with Prof. Robert Langer and Prof. Daniel Anderson at the Koch Institute for Integrative Cancer Research at MIT and received his Ph.D. from the University of Nebraska Medical Center under the mentorship of Prof. Alexander Kabanov.

Beyond OSU
Functional Group: