Richard B. van Breemen, Ph.D.
Aligned with the Linus Pauling Institute, research in the van Breemen laboratory concerns the discovery and development of natural products as chemoprevention agents and the investigation of mechanisms of action and safety of botanical dietary supplements. The goal is to identify micronutrients and natural products that may be used to maintain optimal health and prevent cancer and neurological degenerative diseases. This research integrates the analytical tool of mass spectrometry into all aspects of the drug discovery and development from screening of botanical extracts for the identification of active natural products, to studies of drug metabolism and disposition, and to quantitative analyses of the bioavailability and pharmacokinetics of pharmacologically active compounds. These translational studies extend from basic science to clinical trials.